Title : Genetic Factors in Early Innate Immunity to SARS-CoV-2 in the Upper Respiratory Tract
The nasal epithelium is the initial site of SARS-CoV-2 infection. Early and effective immune responses in the upper respiratory tract (URT) can limit and eliminate the infection in the URT, thereby preventing infection of the lower respiratory tract and the development of severe COVID-19. SARS-CoV-2 interferes with innate immunity signalling and evolves mutants that can reduce antibody-mediated immunity in the URT. Recent genetic and
immunological advances in understanding innate immunity to SARS-CoV-2 in the URT, and the ability of prior infections as well as currently available injectable and potential intranasal COVID-19 vaccines to generate anamnestic adaptive immunity in the URT, are reviewed. It is suggested that the more detailed investigation of URT immune responses to all types of COVID-19 vaccines, and the development of safe and effective COVID-19 vaccines for intranasal administration, are important needs.
Ref: Viruses 2022, 14, 933. https://doi.org/10.3390/v14050933 & Int. J.Mol. Sci. 2021, 22, 7919. https://
What will audience learn from your presentation?
• Cutting edge appreciation of protective immunity to SARS-CoV-2
• Assist teaching
• Help design additional research to advance knowledge of immunity to SARS-CoV-2
• Advance appreciation of the need to develop more effective vaccines
• Help design better vaccines for COVID-19